I agree eliminating dairy helps. I followed a diet for over 2 years that was mainly vegan with fish and my numbers dropped but never to the normal range. What I am interested in is if anyone on Prolia experienced this rapid rise in cholesterol in a very short period of time. One of the side effects listed for Prolia is increased cholesterol levels. I have been on the cholesterol lowering injectable biologic Repatha for three months. Bloodwork done after one week showed a decrease in LDL of 43%!

I can't take oral bisphosphonates so my only option is Aclasta (called Reclast in U.S.). Its given intravenously and frightens me a bit. Given the whole covid scene, I decided to get yet another injection of Prolia. My cholesterol has been abnormally high since my 40's (I am slim with good diet). What changed was the ratio of HDL:LDL and the total number did Sky rocket. Anyway the Repatha has brought it down. My bone density has definitely improved and diet and exercise will never get my bones into the safe zone. I was and probably still am a fracture waiting to happen. Hopefully a better drug will be available in the future. I really do not want to end up in a wheelchair in a long term care facility which is a scary place to be today. Between a rock and a hard place.....

It's more than a year later since the March 2019 post. Have had my 4th Prolia injection. Continuing to show improvement
in both hip and spine.

Six years ago when I found I was unable to tolerate statins, I asked my endocrinologist about niacin. He advised me not to take it as it has g.i. side effects. I have loads of g.i. issues and he said I would have trouble. In any event, the Repatha injections seem to be doing a good job lowering the LDL and no side effects so far.
I really would like to know if there are others out there who saw their LDL numbers spike after being on Prolia.
Thankyou for taking the time to respond.

Hi to Sueand arcades, How interesting to read about your experiences with prolia. I was on it only had 3 shots. At the same time I was on it I discovered a natural product from the US. It's called Algae Cal . It is expensive if you live in Canada especially but to me it was worth it. They have a whole program you can fellow ask questions etc. Plus exercises to follow all on line. Check it out on line .they sometimes advertise on Facebook.
IAfter reading about prolia I decided it was to scared to keep taking it.
I was not aware it could affect cholesterol that would not be good for me.
I have heart disease ,had open heart surgery several yrs. ago need to watch cholesterol on a Statin drug hate taking it but they tell me there is nothing else that effective. And blood pressure as well.
Thank you both for the info. Take care, God Bless. Look forward to chatting again